Etiology:

• Food and nutrition related knowledge deficit
• Contamination, misname, mislabel, misuse, recent brand change, recent dose increase, recent formulation change of substance consumed
• Frequent intake of foods containing bioactive substances
• Altered GI function, eg pain or discomfort

S/S:

• Lab values indicating excessive intake of the specific substance, such as rapid decrease in cholesterol from intake of stanol or sterol esters and a statin drug and related related dietary changes or medications
• Increased hepatic enzyme reflecting hepatocellular damage
• Weight loss as a result of malabsorption or maldigestion
• Neurologic changes, eg anxiety, mental status changes
• Cardiovascular changes, eg heart rate, EKG changes, blood pressure
• Reports or observations of:
• High intake of plant foods containing soy protein, beta glucan, plant sterol and stanol esters, eg fortified margarines, or other foods based on dietary substance, concentrate, metabolite, constituent, extract, or combination
• Substances that interfere with digestion or absorption of foodstuffs
• Ready access to available foods/products with bioactive substance, eg from dietary supplement vendors
• Attempts to use supplements or bioactive substances for weight loss, to treat constipation, or to prevent/cure chronic or acute disease
• Conditions associated with diagnosis or treatment, eg cardiovascular disease, elevated BP, HTN
• Discomfort or pain associated with intake of foods rich in bioactive substances, eg soluble fiber, beta glucan, soy protein