Loss of lean body mass, weight loss

Medications

Endocrine changes (like hypothyroidism)

Increased TSH, decreased T3 and T4

Measured RMR < expected/estimated

Decreased weight or mid-arm muscle circumference

Weight gain (hypothyroidism)

Growth stunting or failure

Decreased adipose or muscle mass

Decreased respiratory rate

Hair loss

Conditions associated with diagnosis or treatment (ie Prader Willi, hypothyroidism, etc)

Bradycardia, hypotension, decreased bowel motility, low body temperature

Cold intolerance, decreased endurance, difficulty concentrating, decreased libido, feelings of anxiety and depression